Prostate Cancer: Treatment Options
Decisions regarding how and when to treat prostate cancer are based largely on the stage of the cancer at the time of diagnosis, whether it is confined to the prostate, or whether it has spread into other areas of the body.
Your doctor will also take into account things like your general health, treatment side effects, and your attitude toward living with these side effects.
Treatment options are aimed at either curing the disease if it has not spread or offering palliative care (relieving pain and symptoms) in order to treat advanced prostate cancer.
Treatment options include:
Watchful waiting/Active surveillance
If your cancer is slow growing and you are not showing any symptoms, your doctor may decide that no treatment is needed immediately. Your doctor will monitor the tumor and start treatment only when he or she thinks it will be of benefit. This is the standard management strategy for many people.
Treatment options include:
Hormone therapies
These therapies treat prostate cancer by reducing the level of testosterone in the blood to inhibit the growth of the cancer. Hormone therapies include LHRH agonists and GnRH antagonists. LHRH agonists cause a surge in testosterone levels before reducing them. A GnRH antagonist works differently, leading to a direct reduction in testosterone levels without any surge.
Chemotherapy
Treatment options to relieve pain and symptoms include chemotherapy, which is used for patients with hormone-refractory prostate cancer, when other therapies have stopped working.
Chemotherapy treatments generally have a high degree of toxicity and have many possible side effects including pain, nausea and vomiting, diarrhea or constipation, anemia, malnutrition, hair loss, memory loss, depression of the immune system, weight loss or gain, and hemorrhage.
Orchiectomy
This surgical procedure removes both of the testicles, in order to reduce testosterone levels. The growth of prostate cancer is dependent on testosterone, and reducing testosterone levels can cause the cancer cells to grow more slowly, stop growing, and even reduce the size of the tumor.
Radical prostatectomy
This surgical procedure removes the prostate gland, seminal vesicles, and often nearby lymph nodes. This major operation has commonly occurring side effects, such as erectile dysfunction and incontinence.
Radiation therapy (Radiotherapy)
Radiation is given from an external machine, or sometimes small radioactive seeds may be inserted into the tumor (brachytherapy). Radiation therapy may be given to cure the patient but has a role in all stages of prostate cancer and may also be combined with hormone treatments.
Low-dose radiation treatments generally cause minimal or no side effects. Higher doses may cause various side effects that are usually limited to the area of the body that is being treated. Possible side effects include skin reactions, swelling, infertility, fatigue, fibrosis, hair loss, and tissue dryness.
WHAT IS FIRMAGON?
FIRMAGON® is a prescription medicine used in the treatment of advanced prostate cancer.
IMPORTANT SAFETY INFORMATION
FIRMAGON® should not be given to people who are allergic to any of the ingredients in FIRMAGON®. It should not be given to women who are pregnant or may become pregnant. FIRMAGON® can harm an unborn baby when given to a pregnant woman.
Before receiving FIRMAGON®, tell your healthcare provider about all your medical conditions, including if you have any heart problems, problems with balance of your body salts or electrolytes (such as, sodium, potassium, calcium, and magnesium), or have kidney or liver problems.
The common side effects of FIRMAGON® include: hot flashes, injection site pain, redness and swelling (especially with the first dose), weight gain, increase in some liver enzymes, tiredness, hypertension, back and joint pain, chills, urinary tract infection, and decrease sex drive and trouble with erectile function (impotence).
The information on this Web site is provided for educational purposes only. While there may be information on this Web site related to certain medical conditions and their treatment, should a medical condition exist, promptly see your own physician or health care provider as the information on this Web site is not intended to take the place of advice from a physician or health care professional. Ferring does not offer personalized medical diagnosis or patient-specific treatment advice. The statements made by doctors on this Web site represent their own individual experiences and opinions and is not intended to be medical advice. Indeed, only your doctor or other health care professional, as a learned intermediary, can determine if a product described in this Web site is appropriate for you.
This Web site is intended for US residents only.
* With continued use, FIRMAGON has been shown to maintain testosterone at medically acceptable levels for up to 1 year.1
** In secondary endpoints of a 1-year, pivotal, phase 3 noninferiority-designed study; FIRMAGON: n=207; leuprolide: n=201.1
References:
1. Klotz L, Boccon-Gibod L, Shore ND, et al. The efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group phase III study in patients with prostate cancer. BJU Int. 2008;102(11):1531-1538. 2. Van Poppel H, Nilsson S. Testosterone surge: rationale for gonadotropin-releasing hormone blockers? Urology. 2008;71(6):1001-1006. 3. Lupron Depot® [package insert]. North Chicago, IL: Abbott Laboratories; 2008. 4. Weckermann D, Harzmann R. Hormone therapy in prostate cancer: LHRH antagonists versus LHRH analogues. Eur Urol. 2004;46(3):279-284.
